PT-141 / Bremelanotide (10mg)

For Laboratory Research Use Only — Not for Human or Animal Consumption. Not for distribution. Must be 18+ to purchase. PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide and direct analog of Melanotan II. It functions as an agonist at melanocortin receptors, with primary activity at MC3R and MC4R subtypes. Unlike Melanotan II, PT-141 lacks a C-terminal amide modification that produced significant blood pressure effects in early research, giving it a more targeted pharmacological profile for CNS melanocortin pathway investigation.

Mechanism of Action

The melanocortin receptor family (MC1R through MC5R) is distributed across both peripheral tissues and the central nervous system. PT-141’s primary research significance derives from its agonism at MC3R and MC4R, which are expressed in hypothalamic and limbic brain regions. These receptors are involved in appetite regulation, energy homeostasis, and autonomic nervous system function. MC4R in the hypothalamus has been extensively studied in the context of CNS-mediated physiological arousal pathways — research that ultimately led to bremelanotide’s pharmaceutical development as an FDA-approved treatment for hypoactive sexual desire disorder. The compound’s CNS mechanism, distinct from peripheral vascular pathways, makes it a reference compound for melanocortin pharmacology research.

Research History

PT-141 emerged from Melanotan II analog research, initially investigated for melanogenic properties. Unexpected CNS-mediated observations during early trials redirected research focus toward its melanocortin receptor activity in the brain. Subsequent laboratory and clinical research characterized binding affinities, CNS distribution, and functional effects at MC3R and MC4R. Bremelanotide was eventually FDA-approved as a pharmaceutical agent — providing an unusual degree of formal clinical validation for a compound also studied as a research peptide.

Active Research Areas

Current research investigates: MC3R and MC4R receptor dynamics in hypothalamic signaling models; melanocortin pathway interaction with dopaminergic and serotonergic systems; melanocortin receptor expression mapping across CNS tissue types; and structure-activity relationships within the cyclic melanocortin agonist compound class.

Specifications

Formulated as a 10mg lyophilized vial for enhanced laboratory stability and reconstitution accuracy. Store sealed away from light contact. Store in a controlled climate matrix at −20°C for long-term research asset protection.

Where can I read the research on PT-141?

We do not paraphrase research findings on this page. For a compound supplied for laboratory use, the primary sources are what matter, and they are public: the peer-reviewed record is indexed on PubMed, and registered clinical studies are listed on ClinicalTrials.gov. Both are maintained by the U.S. National Institutes of Health and are free to search.

How much does PT-141 cost?

PT-141 / Bremelanotide (10mg) is $39.95 per vial, in stock and available for immediate dispatch — that works out to $4.00 per mg, which is the figure worth comparing across suppliers, since headline vial prices are not comparable when vial sizes differ. There are no hidden surcharges, no payment-processor fees added at checkout, and no minimum order. Delivery is costed separately and transparently: same-day Bay Area courier from $19.95 depending on your city, or flat-rate FedEx 2Day nationwide. You can check the exact courier fee for your city before you order. Volume and institutional pricing is available for laboratories ordering in quantity — email support@sfbayareapeptides.com with your requirements.

How is PT-141 tested?

Every lot is independently tested by a third-party laboratory, with identity and purity confirmed by high-performance liquid chromatography (HPLC). Testing is carried out on each lot before it is released for sale.

Where PT-141 sits in the catalog

PT-141 is the sole compound in our Sexual-Function Research category, because its mechanism has no close analog elsewhere in the range: it is a melanocortin receptor agonist acting centrally rather than on the peripheral vascular pathways studied by earlier compound classes. Laboratories working across melanocortin and neuropeptide signalling frequently pair it with compounds from our Neurocognitive Research range, particularly Semax (10mg).

Where can I buy PT-141?

You can buy PT-141 online directly from this page. SF Bay Area Peptides is a San Francisco–based research-compound supplier shipping nationwide, and we hold stock locally rather than drop-shipping — which is why same-day delivery is possible at all. Order before 12:00 p.m. Pacific on a business day and your order qualifies for same-day courier delivery across the San Francisco Bay Area — San Francisco, Oakland, San Jose, Fremont, Sunnyvale, Santa Clara and 100+ more cities. Outside the Bay Area, orders ship FedEx 2Day in temperature-controlled packaging anywhere in the United States. See full delivery zones and pricing. Payment is by debit or credit card at checkout — see how payment works if you would like the detail before ordering. For Laboratory Research Use Only — Not for Human or Animal Consumption. Not for distribution. Must be 18+ to purchase.