Semax (10mg)

For Laboratory Research Use Only — Not for Human or Animal Consumption. Not for distribution. Must be 18+ to purchase. Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog derived from the 4–10 fragment of adrenocorticotropic hormone (ACTH). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, semax extends the bioactive motif of ACTH while resisting rapid enzymatic degradation. It has accumulated extensive research documentation in neuroprotection, neurotrophin regulation, and cognitive function modulation.

Mechanism of Action

Semax operates through multiple documented neurological pathways. It upregulates brain-derived neurotrophic factor (BDNF) and its receptor TrkB, and also promotes nerve growth factor (NGF) expression — positioning it as a direct modulator of neurotrophic signaling critical to neuroplasticity and neuronal survival. Research documents its influence on the dopaminergic system, specifically increased dopamine and serotonin turnover in key brain regions. Semax also modulates expression of genes associated with the brain immune response, suggesting roles in neuroinflammatory research contexts. Unlike ACTH itself, semax does not produce adrenocortical stimulation at research-relevant concentrations.

Research History

Semax was developed through systematic ACTH fragment analog research in the 1980s–1990s. It was approved for clinical use in Russia for neurological applications — one of the few peptide nootropics to have transitioned through formal clinical trials documenting cognitive and neuroprotective outcomes. Published research includes controlled studies on attention and working memory, neuroprotective effects in ischemia models, and quantified BDNF upregulation. Its clinical history distinguishes it from purely theoretical nootropic peptides.

Active Research Areas

Ongoing research examines: BDNF/TrkB pathway modulation kinetics; semax influence in stroke and ischemic injury models; dopaminergic interactions and implications for attention and working memory; comparative neurotrophin upregulation versus other nootropic peptides; and combination studies with selank in anxiety and stress-response research frameworks.

Specifications

Formulated as a 10mg lyophilized vial for enhanced laboratory stability and reconstitution accuracy. Store sealed away from light contact. Store in a controlled climate matrix at −20°C for long-term research asset protection.

Where can I read the research on semax?

We do not paraphrase research findings on this page. For a compound supplied for laboratory use, the primary sources are what matter, and they are public: the peer-reviewed record is indexed on PubMed, and registered clinical studies are listed on ClinicalTrials.gov. Both are maintained by the U.S. National Institutes of Health and are free to search.

How much does semax cost?

Semax (10mg) is $39.95 per vial, in stock and available for immediate dispatch — that works out to $4.00 per mg, which is the figure worth comparing across suppliers, since headline vial prices are not comparable when vial sizes differ. There are no hidden surcharges, no payment-processor fees added at checkout, and no minimum order. Delivery is costed separately and transparently: same-day Bay Area courier from $19.95 depending on your city, or flat-rate FedEx 2Day nationwide. You can check the exact courier fee for your city before you order. Volume and institutional pricing is available for laboratories ordering in quantity — email support@sfbayareapeptides.com with your requirements.

How is semax tested?

Every lot is independently tested by a third-party laboratory, with identity and purity confirmed by high-performance liquid chromatography (HPLC). Testing is carried out on each lot before it is released for sale.

Semax and Selank — how they differ

Both are Russian-developed regulatory peptides and both sit in our Neurocognitive Research category, but they derive from different parent molecules and are studied for different endpoints. Semax is an analog of a fragment of adrenocorticotropic hormone, investigated for BDNF expression, attention and neuroprotection. Selank (10mg) is an analog of the immunomodulatory peptide tuftsin, investigated in anxiolytic and neuroimmune contexts. Their research literatures overlap enough that laboratories commonly acquire both. NAD+ (500mg) completes the category for cellular-energy work.

Where can I buy semax?

You can buy Semax online directly from this page. SF Bay Area Peptides is a San Francisco–based research-compound supplier shipping nationwide, and we hold stock locally rather than drop-shipping — which is why same-day delivery is possible at all. Order before 12:00 p.m. Pacific on a business day and your order qualifies for same-day courier delivery across the San Francisco Bay Area — San Francisco, Oakland, San Jose, Fremont, Sunnyvale, Santa Clara and 100+ more cities. Outside the Bay Area, orders ship FedEx 2Day in temperature-controlled packaging anywhere in the United States. See full delivery zones and pricing. Payment is by debit or credit card at checkout — see how payment works if you would like the detail before ordering. For Laboratory Research Use Only — Not for Human or Animal Consumption. Not for distribution. Must be 18+ to purchase.