CJC-1295 Without DAC (10mg)

For Laboratory Research Use Only — Not for Human or Animal Consumption. Not for distribution. Must be 18+ to purchase. CJC-1295 Without DAC (also known as Mod GRF 1-29) is a synthetic analog of growth hormone-releasing hormone (GHRH), specifically the biologically active N-terminal fragment comprising residues 1–29. It incorporates four amino acid substitutions relative to native GHRH(1-29) to improve receptor binding affinity and plasma stability, without the Drug Affinity Complex (DAC) modification used in its longer-acting counterpart.

Mechanism of Action

CJC-1295 Without DAC binds to the GHRH receptor (GHRHR) on anterior pituitary somatotrophs, triggering endogenous GH release in a pulsatile pattern. Because it lacks the DAC albumin-binding modification, it maintains a shorter active window consistent with natural GHRH signaling dynamics, producing discrete GH pulses rather than the prolonged elevation associated with DAC-modified analogs. This natural-pulse profile is often preferred in research where investigators wish to study physiological GH secretion patterns rather than sustained GH elevation.

Research History

GHRH(1-29) was identified as the minimal active GHRH fragment in foundational endocrinology research. Subsequent analog development including the CJC-1295 modifications aimed to preserve pulsatile GH secretion while improving stability against enzymatic degradation. The without-DAC form has been used extensively in comparative studies examining how natural GH pulse characteristics affect downstream IGF-1 production and somatotropic axis signaling.

Active Research Areas

Current investigations include: GHRHR binding dynamics and receptor desensitization; synergistic GH axis activation in combination with GHRPs such as ipamorelin; influence of natural-pulsatile GH patterns on IGF-1 regulation; and comparative studies across GHRH analog variants. Widely used in metabolic and body composition research models involving the GH/IGF-1 axis.

Specifications

Formulated as a 10mg lyophilized vial for enhanced laboratory stability and reconstitution accuracy. Store sealed away from light contact. Store in a controlled climate matrix at −20°C for long-term research asset protection.

Where can I read the research on CJC-1295 Without DAC?

We do not paraphrase research findings on this page. For a compound supplied for laboratory use, the primary sources are what matter, and they are public: the peer-reviewed record is indexed on PubMed, and registered clinical studies are listed on ClinicalTrials.gov. Both are maintained by the U.S. National Institutes of Health and are free to search.

How much does CJC-1295 Without DAC cost?

CJC-1295 Without DAC (10mg) is $39.00 per vial, in stock and available for immediate dispatch — that works out to $3.90 per mg, which is the figure worth comparing across suppliers, since headline vial prices are not comparable when vial sizes differ. There are no hidden surcharges, no payment-processor fees added at checkout, and no minimum order. Delivery is costed separately and transparently: same-day Bay Area courier from $19.95 depending on your city, or flat-rate FedEx 2Day nationwide. You can check the exact courier fee for your city before you order. Volume and institutional pricing is available for laboratories ordering in quantity — email support@sfbayareapeptides.com with your requirements.

How is CJC-1295 Without DAC tested?

Every lot is independently tested by a third-party laboratory, with identity and purity confirmed by high-performance liquid chromatography (HPLC). Testing is carried out on each lot before it is released for sale.

Why “Without DAC” matters

The DAC (Drug Affinity Complex) modification extends CJC-1295’s half-life substantially. The without-DAC presentation supplied here does not carry that modification, which is precisely why researchers specify it: the shorter half-life is what makes pulsatile-release modelling possible. If your protocol calls for sustained elevation rather than pulsatile signalling, this is not the presentation you want. CJC-1295 acts on the GHRH receptor. Ipamorelin (10mg) acts on the ghrelin receptor — a separate pathway converging on the same output, which is why the two are the most commonly co-acquired pair in our Growth Hormone & Recovery category.

Where can I buy CJC-1295 Without DAC?

You can buy CJC-1295 Without DAC online directly from this page. SF Bay Area Peptides is a San Francisco–based research-compound supplier shipping nationwide, and we hold stock locally rather than drop-shipping — which is why same-day delivery is possible at all. Order before 12:00 p.m. Pacific on a business day and your order qualifies for same-day courier delivery across the San Francisco Bay Area — San Francisco, Oakland, San Jose, Fremont, Sunnyvale, Santa Clara and 100+ more cities. Outside the Bay Area, orders ship FedEx 2Day in temperature-controlled packaging anywhere in the United States. See full delivery zones and pricing. Payment is by debit or credit card at checkout — see how payment works if you would like the detail before ordering. For Laboratory Research Use Only — Not for Human or Animal Consumption. Not for distribution. Must be 18+ to purchase.