NAD+ (500mg)

For Laboratory Research Use Only — Not for Human or Animal Consumption. Not for distribution. Must be 18+ to purchase. NAD+ (nicotinamide adenine dinucleotide) is a dinucleotide coenzyme found in all living cells, functioning as an essential electron carrier in cellular metabolism and as a substrate for critical regulatory enzymes. It participates in hundreds of metabolic reactions and is considered a master regulator of cellular energy homeostasis. NAD+ levels decline progressively with age in human tissue — a phenomenon that has generated significant research interest in NAD+ precursor supplementation and direct coenzyme research applications.

Mechanism of Action

NAD+ operates through two primary research-relevant mechanisms. As a redox coenzyme: NAD+ accepts electrons during glycolysis, the citric acid cycle, and fatty acid oxidation to form NADH, which donates those electrons to Complex I of the mitochondrial respiratory chain to drive ATP synthesis. This electron-carrier function is fundamental to aerobic energy production. As a regulatory enzyme substrate: sirtuins (SIRT1–SIRT7) use NAD+ as a co-substrate for deacetylation reactions that regulate gene expression, mitochondrial biogenesis, and cellular stress responses. PARP enzymes also draw on NAD+ during DNA damage repair, creating a competitive demand that connects NAD+ availability to genomic stability maintenance.

Research History

NAD+’s role in cellular metabolism has been understood since foundational biochemistry research in the early 20th century. Active contemporary research interest intensified with the discovery of sirtuins’ NAD+-dependence — a finding connecting NAD+ availability to lifespan regulation in model organisms. Landmark studies documented NAD+ decline in aging tissues and reversal of certain age-associated phenotypes in animal models through NAD+ precursor restoration. These findings established NAD+ metabolism as a central axis of aging biology research.

Active Research Areas

Current research investigates: sirtuin activation dynamics under varying NAD+ concentrations; PARP enzyme activity and interaction with cellular NAD+ pools during DNA damage; mitochondrial biogenesis signaling downstream of SIRT1/PGC-1α activation; NAD+ precursor comparison studies (NMN vs NR) for tissue-specific NAD+ restoration; and CD38 as a major NAD+-utilizing enzyme in age-related NAD+ decline models.

Specifications

Formulated as a 500mg lyophilized vial for enhanced laboratory stability and reconstitution accuracy. Store sealed away from light contact. Store in a controlled climate matrix at −20°C for long-term research asset protection.

Where can I read the research on NAD+?

We do not paraphrase research findings on this page. For a compound supplied for laboratory use, the primary sources are what matter, and they are public: the peer-reviewed record is indexed on PubMed, and registered clinical studies are listed on ClinicalTrials.gov. Both are maintained by the U.S. National Institutes of Health and are free to search.

How much does NAD+ cost?

NAD+ (500mg) is $49.95 per vial, in stock and available for immediate dispatch — that works out to $0.10 per mg, which is the figure worth comparing across suppliers, since headline vial prices are not comparable when vial sizes differ. There are no hidden surcharges, no payment-processor fees added at checkout, and no minimum order. Delivery is costed separately and transparently: same-day Bay Area courier from $19.95 depending on your city, or flat-rate FedEx 2Day nationwide. You can check the exact courier fee for your city before you order. Volume and institutional pricing is available for laboratories ordering in quantity — email support@sfbayareapeptides.com with your requirements.

How is NAD+ tested?

Every lot is independently tested by a third-party laboratory, with identity and purity confirmed by high-performance liquid chromatography (HPLC). Testing is carried out on each lot before it is released for sale.

Compounds studied alongside NAD+

NAD+ sits in our Neurocognitive Research category alongside the regulatory peptides most often used in cognition and neuroprotection models — Semax (10mg) and Selank (10mg). At 500mg it is by far the largest vial we stock, which is why its per-milligram cost sits an order of magnitude below every peptide in the catalog.

Where can I buy NAD+?

You can buy NAD+ online directly from this page. SF Bay Area Peptides is a San Francisco–based research-compound supplier shipping nationwide, and we hold stock locally rather than drop-shipping — which is why same-day delivery is possible at all. Order before 12:00 p.m. Pacific on a business day and your order qualifies for same-day courier delivery across the San Francisco Bay Area — San Francisco, Oakland, San Jose, Fremont, Sunnyvale, Santa Clara and 100+ more cities. Outside the Bay Area, orders ship FedEx 2Day in temperature-controlled packaging anywhere in the United States. See full delivery zones and pricing. Payment is by debit or credit card at checkout — see how payment works if you would like the detail before ordering. For Laboratory Research Use Only — Not for Human or Animal Consumption. Not for distribution. Must be 18+ to purchase.